Synthesis and anticancer activity of novel 2-BEnzyl-6-(Substituted phenyl)-Imidazo[2,1-B] [1,2,3] thiadiazole derivatives
By: Singh, S
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Contributor(s): Kaur, Amandeep.
Publisher: Mumbai Indian Drug Manufacturers Association 2019Edition: Vol. 56(04), April.Description: 13-20p.Subject(s): DRUG STORE MANAGEMENTOnline resources: Click here
In:
Indian drugsSummary: A new series of 2-benzyl-6-(substituted phenyl)-imidazo[2,1-b][1,3,4] thiadiazoles (S1-S8) was synthesized as potential anti-cancer agents. These compounds were evaluated for their anticancer activity against various cancer cell lines. The anticancer activity data reveals that the compounds S1 (2-benzyl- 6-phenylimidazo[2,1-b][1,3,4]thiadiazole) showed maximum growth inhibition against CNS cancer cell lines while the compounds S2 (2-benzyl-6-(4-chlorophenyl) imidazo[2,1-b][1,3,4] thiadiazole) and S3 (2-benzyl-6-(2,4-dichlorophenyl)imidazo[2,1-b][1,3,4] thiadiazole) showed maximum inhibition against leukemia cell lines. The compounds S5 (2-(2-benzylimidazo[2,1-b] [1,3,4]thiadiazol-6-yl) phenol) and S6 (4-(2-benzylimidazo[2,1-b][1,3,4] thiadiazol-6-yl)benzene-1,3-diol) showed maximum inhibition against renal cancer cell lines and the compound S7 (3-(2-benzylimidazo[2,1-b][1,3,4] thiadiazol-6-yl) benzenamine) was most active against non-small cell lung cancer cell lines.
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School of Pharmacy Archieval Section | Not for loan | 2018522 |
A new series of 2-benzyl-6-(substituted phenyl)-imidazo[2,1-b][1,3,4] thiadiazoles (S1-S8) was synthesized as potential anti-cancer agents. These compounds were evaluated for their anticancer activity against various cancer cell lines. The anticancer activity data reveals that the compounds S1 (2-benzyl- 6-phenylimidazo[2,1-b][1,3,4]thiadiazole) showed maximum growth inhibition against CNS cancer cell lines while the compounds S2 (2-benzyl-6-(4-chlorophenyl) imidazo[2,1-b][1,3,4] thiadiazole) and S3 (2-benzyl-6-(2,4-dichlorophenyl)imidazo[2,1-b][1,3,4] thiadiazole) showed maximum inhibition against leukemia cell lines. The compounds S5 (2-(2-benzylimidazo[2,1-b] [1,3,4]thiadiazol-6-yl) phenol) and S6 (4-(2-benzylimidazo[2,1-b][1,3,4] thiadiazol-6-yl)benzene-1,3-diol) showed maximum inhibition against renal cancer cell lines and the compound S7 (3-(2-benzylimidazo[2,1-b][1,3,4] thiadiazol-6-yl) benzenamine) was most active against non-small cell lung cancer cell lines.
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